AVANCES EN GENÓMICA NUTRICIONAL Y SU USO EN LA NUTRICIÓN PERSONALIZADA PARA EL TRATAMIENTO DE LA OBESIDAD

Abstract

Introduction: This literature review explores advances in nutritional genomics and its application in personalized nutrition to address obesity. Considering the complexity of the human genome and genetic susceptibilities to diseases like obesity, personalized nutrition emerges as a promising solution for this multifactorial disease that impacts global public health. Objective: The aim of the study is to identify the most effective nutraceuticals in personalized nutrition to mitigate or treat obesity through specific dietary adjustments based on individual genetics. Methodology: A non-systematic review of scientific literature published between 2019 and 2023 was conducted, selecting studies based on criteria of relevance, accessibility, and timeliness. Of the 82 articles evaluated, 40 met the inclusion criteria. Results: The selected studies highlight the importance of compounds such as quercetin, curcumin, resveratrol, and anthocyanins in modulating the genetic and metabolic response to obesity. These nutraceuticals have been demonstrated to be effective in reducing adiposity and related inflammation. Discussion: Nutrigenetics and nutrigenomics are essential for personalizing nutrition, as individual genetic variability significantly affects the response to different diets and treatments, justifying a personalized approach that considers the specific genotype of the individual. Conclusion: Integrating nutraceuticals into the diet based on the genetic profile may be key to the effective management and treatment of obesity. Research points towards a shift to personalized nutrition, emphasizing the need for more studies and their implementation in clinical and dietary practices.