Ciencias Agropecuarias

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    Efecto de la infusión continua de dexmedetomidina sobre la concentración alveolar mínima (CAM) de sevoflurano y eficiencia anestésica en ovariohisterectomía en conejos (Oryctolagus cuniculus)
    (2024-08) Chisag Caiza, Gissela Fernanda; Lozada Ortiz, Jenny Piedad
    The purpose of this research was to evaluate the effect of continuous infusion of dexmedetomidine on the minimum alveolar concentration (MAC) of sevoflurane and anesthetic efficiency in ovariohysterectomy in rabbits (Oryctolagus cuniculus). Twenty-four clinically healthy 7-month-old female rabbits with an-ASA I and weighing 1.8-3 kg were used. These patients were subjected to a 6-hour fast of solids and 1-hour of liquids prior to the intervention. A completely randomized design with three treatments (two experimental) and a control treatment was applied. The animals were divided by treatments with 8 animals each, that is, T1=8 rabbits, T2=8 rabbits and T3=8 rabbits. In treatment T1, an anesthetic protocol based on ketamine (15mg/kg), midazolam (0.2mg/kg) for premedication was administered intramuscularly (IM), while propofol (2mg/kg) was used intravenously (IV) for induction, In maintenance, sevoflurane was used according to the patient's requirement, at an initial CAM of 3.7% accompanied by a constant rate infusion (CRI), at a dose of 3.5 ug/kg/h of dexmedetomidine. In the second treatment the same anesthetic protocol was used with ketamine (15mg/kg), midazolam (0.2mg/kg) for intramuscular (IM) premedication, propofol (2mg/kg) was used intravenously (IV) for induction, and sevoflurane was used for maintenance according to the patient's requirement, in an initial CAM of 3.7% accompanied by a continuous infusion CRI at a dose of 5 ug/kg/h of dexmedetomidine. In the control treatment T3 the continuous infusion was not applied and a continuous drip of 0.9% sodium chloride was administered applying the same anesthetic protocol mentioned above. The physiological parameters to be evaluated were heart rate, respiratory rate, systolic blood pressure, diastolic blood pressure, mean arterial blood pressure, oxygen saturation, and sevoflurane CAM assessment. By means of an analysis of variance, the best result obtained was with the T2 treatment with an CRI at a dose of 5 ug/kg/h of dexmedetomidine, which does not present significant differences in most of the parameters, keeping them stable; however, a reduction of the CAM at 1.34% of sevoflurane was observed.