Ciencias de la Salud

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Subject: search.filters.subject.INHIBIDORES

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    Hemofilia a y b: manejo del paciente con inhibidores
    (Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Medicina, 2022-11) Núñez Pérez, Eliana Alejandra; Naranjo Perugachi, Jeaneth del Carmen Dra.
    Hemophilia is an affection defined by a hereditary and congenital hemorrhagic alteration in which the blood does not coagulate properly, causing hemorrhages spontaneously or after witnessing an injury or surgical procedure, mainly manifested by mutations in the chromosome X, in which there is a decrease or absence of the activity of factors VIII or IX, within this pathology inhibitors can be produced, these being alloantibodies that act against coagulation factor VIII and IX, which are responsible for the suspension of bleeding, the presence of inhibitors can be suspected when the bleeding does not stop with the usual dose of treatment, which are the concentrates of said factors. In this review, sources that contain verified and real information were investigated in publications of scientific journals such as The New England Journal of Medicine, The official Journal of the World Federation of Hemophilia, Haematologica, WHO and databases such as Scopus, PubMed, The Cochrane, Google Scholar, Uptodate, BMC Medicine with a period of time between 2016 and 2021 in the Spanish and English languages. This pathology requires an interdisciplinary, complex and often costly management. Treatment depends on the location and severity of the bleeding, the titer and the characteristics of the inhibitor. Among the drugs used to manage this pathology are recombinant activated FVII rFVIIa, activated prothrombin complex concentrates (APCC) and the use of Rituximab and Emicizumab
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    Factores laborales asociados a la Intoxicación crónica por inhibidores de la Colinesterasa en trabajadores agrícolas de San Vicente, Cantón Quero 2015-2016
    (Universidad Técnica de Ambato-Facultad de Ciencias de la Salud-Dirección de Posgrado, 2016-11-01) Robalino Travez, Teresa LilianaMd.; Sunta Ruiz Dr. Esp, Mario Leopoldo
    Introduction: A global pesticide use has increased, which implies a risk for the working population, but unfortunately did not use the correct protective equipment that relates for lack of knowledge, so that there is direct exposure. So the World Health Organization estimates that worldwide more than 750,000 people would present some kind of chronic effect by being in contact with pesticides Objective: To identify factors related to occupational chronic exposure to cholinesterase inhibitors in farm workers, San Vicente, Quero 2015-2016. Methodology: an observational, descriptive, cross-sectional study presents the universe of study constituted 200 farm workers took a sample of 97 but only 78 met the inclusion criteria. Results: It was noted that there is a misuse of pesticides by lack of information and training in 67% of agricultural workers. Protective equipment used boots were 100%, 20.5% mask and gloves 3.8%. In addition low levels of erythrocyte cholinesterase was identified in 84.4% of men and 39.9% in women, exposure time in years and the frequency of use is directly proportional; therefore the longer and more often exposed percent have low values. By analyzing neurological, neuropsychological and cognitive disorders, both men and women had involvement at all scale