Ciencias de la Salud
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Item “Niveles séricos de anticuerpos anti-peroxidasa tiroidea (anti-tpo) en sujetos pediátricos con los trastornos del espectro autista (tea) y su correlación con los niveles séricos maternos”,(Universidad Técnica de Ambato - Facultad de Ciencias de la Salud - Carrera de Laboratorio Clínico, 2018-09-01) Poaquiza Gallegos, Lucía Elizabeth; Arraiz de Fernandez, Carolina Md. Esp.This research project was to determine and to correlate serum levels of anti-TPO antibodies in mothers of pediatric subjects with ASD and their children compared with controls which were mothers and their children with typical development. We analyzed serum levels of anti-TPO antibodies to check if there were a direct association with the development of ASD. Methodologically, it was used a descriptive cross-sectional and correlational analysis; doing the research in field and laboratory. We worked with 88 patients, of which 30 were pediatric subjects aged between 3 - 17 years of age with Autism Spectrum Disorders, their mothers, and 14 children with neurotypical development and their mothers, who underwent the quantitative analysis of serum levels of anti-TPO. The quantification of serum levels of anti-TPO was carried out using the test method of enzyme-linked immunosorbent assay (ELISA). For the correlation of serum levels of anti-TPO of ASD children and their mothers we use statistical methods of Odds Ratio (OR), and Pearson. The analysis determined that 100% of the pediatric subjects with ASD presented normal serum (values of less than 40IU/ml): 3.3% of the mothers of the pediatric subjects with ASD presented high serum levels of anti-TPO antibodies (greater than 40IU/ml). On the other hand the 7.1% of the mothers of children with typical development presented high serum levels of anti-TPO antibodies. The analysis of correlation (r) of anti-TPO antibodies serum levels in pediatric subjects with ASD and their mothers presented a Pearson´s correlation of 0.207. The correlation of anti-TPO antibodies serum levels in pediatric subjects with typical development and their mothers presented a negative very low Pearson´s correlation of –0.01. Concluding that the serum levels of anti-TPO antibodies of mothers has no correlation with the development of ASD.Item “Determinación de gama GT y colinesterasa y su relación como marcadores de recaída en alcohólicos”(Universidad Técnica de Ambato - Facultad de Ciencias de la Salud - Carrera de Laboratorio Clínico, 2017-04-01) Silva Flores, Nancy Fernanda; Bqf. Ramos Ramírez, Martha Cecilia Mg.The purpose of this research project was to carry out chemical analysis, mainly the determination of the concentrations of the enzymes Gamma GT and serum Cholinesterase in anonymous alcoholic patients of the Guild of Tungurahua, through a set of activities that included visiting the patients of the Center of Recovery, applying surveys to know more about their quality of life, risk factors and what diseases can carry this substance in the liver, through laboratory tests. In this study a qualitative and quantitative approach was used, since it was in contact with the anonymous alcoholic patients of the Guild of Tungurahua giving a clear and concise perspective to give to understand the development of the investigation and by the laboratory tests that will take finished. All data from the survey and the results of the laboratory tests obtained were taken in numbers and percentages that appear as graphs. The importance of evaluating the enzymes Gamma GT and Cholinesterase in alcoholic patients constitutes a fundamental pillar within a medical assessment to rule out or confirm an alteration of the concentration of the enzymes that are usually markers of liver damage. In conclusion, it was determined that all the anonymous alcoholic patients of the Guild of Tungurahua performed the laboratory tests as GT Range and Cholinesterase; Which exceeded the normal reference values; Since they were not within the normal range; In general the patients studied have several factors that have influenced the development of the disease, such as the time of consumption, the onset of addiction, time of exposure, social, personal and socioeconomic problems that led to an addiction.