Ciencias de la Salud

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Start date: 2024Subject: search.filters.subject.DISBIOSIS

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    ASOCIACIÓN ENTRE LA COMPOSICIÓN DE LA MICROBIOTA INTESTINAL: RELACIÓN CON LA ENFERMEDAD CELIACA Y DESNUTRICIÓN
    (2025-06-19) Maridueña Paredes, Lizbeth Sarahi; Torres Torres, Johny Mauricio; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Medicina
    The aim was to determine the association between the composition of the intestinal microbiota and its relationship with celiac disease and malnutrition. A systematic review was carried out following the PRISMA guidelines, using databases such as PubMed, Dialnet, Google Scholar, SciELO and Elsevier. Studies published between 2020 and 2024 in Spanish and English, which analysed the composition of the intestinal microbiota in patients with celiac disease, were included. The selection of studies was carried out through a threephase process: review of titles and abstracts, evaluation of the full text and final data extraction. The results revealed an intestinal dysbiosis characterised by a significant reduction in beneficial bacteria (Bifidobacterium and Lactobacillus) and an increase in potentially pathogenic bacteria (Bacteroides and Escherichia coli). These microbial alterations are not only a consequence of celiac disease, but play a fundamental role in its development. Microbial changes were identified up to 18 months before clinical manifestation, suggesting their potential as an early biomarker. Factors such as antibiotic use, birth route and type of feeding significantly influence the composition of the microbiota. In conclusion, the intestinal microbiota plays a crucial role in the pathogenesis of celiac disease and malnutrition. Microbial alterations compromise nutrient absorption, modify the immune response and affect intestinal permeability. Emerging therapeutic strategies focus on microbiota modulation through probiotics, prebiotics and fecal microbiota transplantation, representing a promising approach for the management of these conditions.
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    TRASPLANTE DE MICROBIOTA FECAL COMO NUEVA TERAPÉUTICA EN EL MANEJO DE LA DIABETES MELLITUS TIPO 2
    (2025-06-16) Acosta Cañar, Kerly Joselyn; Recalde Navarrete, Ricardo Javier; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Medicina
    Introduction: Type 2 diabetes mellitus (DM2) is a global public health problem, and is one of the main causes of disability, premature death and complications, resulting from poor glycemic control, poor monitoring and underlying chronic pathologies. The budget for care is increasingly scarce, which is why there is a need to find new cost-effective therapeutic options that offer multiple benefits and contribute to achieving therapeutic objectives. Objective: to determine the efficacy of fecal microbiota transplantation as a new therapy in the management of type 2 diabetes. Results: in the literature review of both human and animal models using FMT, a reduction in blood glucose values, body mass index (BMI), glycosylated hemoglobin (HbA1c), systolic blood pressure, triglycerides and total cholesterol is reported, improving cost-effectiveness in treatment. Conclusion: FTM is an excellent cost-effective alternative or complementary to conventional treatment of type 2 DM; the benefits are significant in terms of therapy and budget reduction in health systems, however, in developing countries its implementation is not feasible.
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    EFECTO TERAPÉUTICO DE LOS PROBIÓTICOS COMO TRATAMIENTO COADYUVANTE PARA EL TRASTORNO DEPRESIVO MAYOR
    (2025-06-13) Caiza Bustos, Anabel Estefania; Acosta Gavilánez, Roberto Iván; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Medicina
    Introduction: In the field of mental health, factors such as unbalanced diet, infections, and sustained stress lead to alterations in the functions of the intestinal microbiota, including the synthesis of neuroactive compounds. Probiotics are attributed a potential therapeutic effect in pathologies such as major depressive disorder (MDD) by modulating the gut-brain microbiota axis. Objective: To identify probiotic strains that have potential effects on the symptoms of major depressive disorder. Materials and methods: A descriptive bibliographic review was carried out with information collected from meta-analyses, systematic reviews, randomized controlled studies, bibliographic reviews, intervention studies, pilot studies obtained from specialized databases such as PubMed, ScienceDirect and Cochrane Library published between 2020 and 2024.Conclusions: The effects are specific to each strain. The capacity of Lactobacillus helveticus and Bifidobacterium longum to boost tryptophan along the serotonin pathway, improving mood, anhedonia and sleep quality, is highlighted. Bifidobacterium breve CCFM1025 regulates the serotonergic system and the metabolism of tryptophan, a precursor of serotonin, capable of alleviating the symptoms of MDD. Despite the positive findings around the strains studied, research in larger populations is required to determine the efficacy and safety of probiotic supplementation to the classic treatment of MDD.
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    EFECTO DE LOS PROBIÓTICOS EN EL PACIENTE OBESO. UN ESTUDIO DE REVISIÓN
    (Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Nutrición y Dietética, 2024-09-25) Montachana Crespata, Milena Alexandra; Viteri Robayo, Carmen Patricia
    Introduction: The gut microbiota is a potential determining factor in the development of obesity, resulting in dysbiosis, which is related to a lower number of members of the Bacteroidetes division and an increase in Firmicutes leading to a decrease in energy expenditure, it is also associated with the inflammatory process, insulin resistance and type 2 diabetes mellitus. Objective: To carry out a literature review related to the effects of probiotics on the improvement of the intestinal microbiota in an obese patient and its associated disorders. Methods: A search of articles in PubMed, Google Scholar and Elsevier from the last five years was carried out using the terms "obesity and probiotics", "effect of probiotics", "gut microbiota and probiotics". A total of 23 articles were included in the selection criteria. Results: Supplementation with probiotics specifically certain strains such as Lactobacillus plantarum and Bifidobacterium could lead to significant weight reductions, in combination with energy restriction and physical activity. However, it is important to develop clinical trials that are properly designed, including all aspects of lifestyle, gut microbiota, metabolites, and genetic background. Conclusions: Despite the beneficial effects, they are not yet considered an alternative strategy in the treatment of obesity due to the lack of research in this field, since the currently available data come from studies carried out in animals that may not present potential in humans. It is important to conduct more large-scale longitudinal studies with longer follow-up.
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    MICROBIOTA INTESTINAL EN LA OBESIDAD: REVISIÓN BIBLIOGRÁFICA
    (Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Nutrición y Dietética, 2024-09-20) Gutierrez Lozada, Andres Eduardo; Guangasig Toapanta, Víctor Hernán
    Obesity and overweight is the abnormal and excessive accumulation of body fat. In recent decades they have become a global public health problem. The intestinal microbiota, which is the microbial ecosystem that colonizes the gastrointestinal tract, is involved in the pathogenesis of obesity. The objective of the present review is to compile the latest advances on the relationship between the intestinal microbiota in obesity and establish dysbiosis as an important factor in obesity, as well as the influence of diet on the intestinal microbiota and the consumption of prebiotics and probiotics. . . A methodology was used based on the bibliographic review of research related to the microbiota and obesity, carried out by exploring digital platforms specialized in health, such as Pubmed, Google Academic, ScIELO and Dialnet, in the period between 2019 and 2023. The results revealed that an imbalance in the intestinal microbiota is associated with an increased risk of obesity and related diseases. It is clear that the intestinal microbiota plays an important role in the pathogenesis of obesity.