Laboratorio Clínico

Permanent URI for this collectionhttp://repositorio.uta.edu.ec/handle/123456789/817

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Ácido úrico como biomarcador predictivo de la preeclampsia
(Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Laboratorio Clínico, 2023-09-21) Ricachi Sulca, Daniel Stalin; Rosero Freire, Daniela Alexandra
Preeclampsia is a hypertensive complication of pregnancy, which is associated with high levels of maternal and fetal morbidity. About 5 to 8% of pregnancies are affected by this gestational disorder. Renal, cardiac, pulmonary, hepatic, neurologic dysfunction; hematologic disorders; fetal growth restriction; stillbirth; and maternal death are the serious complications that can occur in preeclampsia. Hyperuricemia is a biomarker that shows the progression of gestational hypertension and the risk of fetal and maternal complications as it induces the release of proinflammatory cytokines, such as TNF-α, IL-1β and IL6. According to different investigations, authors indicate that high uric acid levels were notable in the second trimester in women who developed preeclampsia. Investigators estimate concentrations reported to be 6.08 ± 0.49 mg/dL versus 5.20 ± 0.19 mg/dL, and emphasize that at least 25.9% of hyperuricemic preeclamptic women (>6 mg/dL) were referred to the special care unit. The present study aims to collect current information with the purpose of clarifying the role of uric acid as a predictive biomarker in preeclampsia, in order to determine its diagnostic value in this gestational complication.
Importancia en la determinación de niveles séricos de ácido úrico, colesterol y triglicéridos en mujeres gestantes
(Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Laboratorio Clínico, 2024-03-04) Guadalupe Carrasco, Ana Lizbeth; Ramos Ramírez, Martha Cecilia
The fundamental importance of the analytes lies in their role as primary biomarkers to identify possible conditions that may arise during the gestation process. Objective: To analytes the importance of determining uric acid, cholesterol and triglycerides in pregnant women. Methodology: The article was a literature review that focused on the synthesis and analysis of scientific articles related to the topic in question. The PRISMA method was used to search for information, which consisted of an exhaustive and systematic search for relevant data using appropriate search terms and strategies. Results: Thirteen articles were screened and selected for analysis, of which six were excluded because they focused on pregnant women, but with different analytes. From the standards, 7 articles were identified that met the methodology and were included in the article development analysis. Conclusions: The research evidenced that the evaluation of uric acid, cholesterol and triglyceride levels are a first source in preclinical diagnosis, however, among the most common pathologies such as preeclampsia there are approximately 66 predictive parameters being this an important part of prenatal care to promote a healthy pregnancy.