Medicina

Permanent URI for this collectionhttp://repositorio.uta.edu.ec/handle/123456789/815

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    ASOCIACIÓN ENTRE LA COMPOSICIÓN DE LA MICROBIOTA INTESTINAL: RELACIÓN CON LA ENFERMEDAD CELIACA Y DESNUTRICIÓN
    (2025-06-19) Maridueña Paredes, Lizbeth Sarahi; Torres Torres, Johny Mauricio; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Medicina
    The aim was to determine the association between the composition of the intestinal microbiota and its relationship with celiac disease and malnutrition. A systematic review was carried out following the PRISMA guidelines, using databases such as PubMed, Dialnet, Google Scholar, SciELO and Elsevier. Studies published between 2020 and 2024 in Spanish and English, which analysed the composition of the intestinal microbiota in patients with celiac disease, were included. The selection of studies was carried out through a threephase process: review of titles and abstracts, evaluation of the full text and final data extraction. The results revealed an intestinal dysbiosis characterised by a significant reduction in beneficial bacteria (Bifidobacterium and Lactobacillus) and an increase in potentially pathogenic bacteria (Bacteroides and Escherichia coli). These microbial alterations are not only a consequence of celiac disease, but play a fundamental role in its development. Microbial changes were identified up to 18 months before clinical manifestation, suggesting their potential as an early biomarker. Factors such as antibiotic use, birth route and type of feeding significantly influence the composition of the microbiota. In conclusion, the intestinal microbiota plays a crucial role in the pathogenesis of celiac disease and malnutrition. Microbial alterations compromise nutrient absorption, modify the immune response and affect intestinal permeability. Emerging therapeutic strategies focus on microbiota modulation through probiotics, prebiotics and fecal microbiota transplantation, representing a promising approach for the management of these conditions.
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    TRASPLANTE DE MICROBIOTA FECAL COMO NUEVA TERAPÉUTICA EN EL MANEJO DE LA DIABETES MELLITUS TIPO 2
    (2025-06-16) Acosta Cañar, Kerly Joselyn; Recalde Navarrete, Ricardo Javier; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Medicina
    Introduction: Type 2 diabetes mellitus (DM2) is a global public health problem, and is one of the main causes of disability, premature death and complications, resulting from poor glycemic control, poor monitoring and underlying chronic pathologies. The budget for care is increasingly scarce, which is why there is a need to find new cost-effective therapeutic options that offer multiple benefits and contribute to achieving therapeutic objectives. Objective: to determine the efficacy of fecal microbiota transplantation as a new therapy in the management of type 2 diabetes. Results: in the literature review of both human and animal models using FMT, a reduction in blood glucose values, body mass index (BMI), glycosylated hemoglobin (HbA1c), systolic blood pressure, triglycerides and total cholesterol is reported, improving cost-effectiveness in treatment. Conclusion: FTM is an excellent cost-effective alternative or complementary to conventional treatment of type 2 DM; the benefits are significant in terms of therapy and budget reduction in health systems, however, in developing countries its implementation is not feasible.
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    EFECTO TERAPÉUTICO DE LOS PROBIÓTICOS COMO TRATAMIENTO COADYUVANTE PARA EL TRASTORNO DEPRESIVO MAYOR
    (2025-06-13) Caiza Bustos, Anabel Estefania; Acosta Gavilánez, Roberto Iván; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Medicina
    Introduction: In the field of mental health, factors such as unbalanced diet, infections, and sustained stress lead to alterations in the functions of the intestinal microbiota, including the synthesis of neuroactive compounds. Probiotics are attributed a potential therapeutic effect in pathologies such as major depressive disorder (MDD) by modulating the gut-brain microbiota axis. Objective: To identify probiotic strains that have potential effects on the symptoms of major depressive disorder. Materials and methods: A descriptive bibliographic review was carried out with information collected from meta-analyses, systematic reviews, randomized controlled studies, bibliographic reviews, intervention studies, pilot studies obtained from specialized databases such as PubMed, ScienceDirect and Cochrane Library published between 2020 and 2024.Conclusions: The effects are specific to each strain. The capacity of Lactobacillus helveticus and Bifidobacterium longum to boost tryptophan along the serotonin pathway, improving mood, anhedonia and sleep quality, is highlighted. Bifidobacterium breve CCFM1025 regulates the serotonergic system and the metabolism of tryptophan, a precursor of serotonin, capable of alleviating the symptoms of MDD. Despite the positive findings around the strains studied, research in larger populations is required to determine the efficacy and safety of probiotic supplementation to the classic treatment of MDD.