Medicina

Permanent URI for this collectionhttp://repositorio.uta.edu.ec/handle/123456789/815

Browse

Has files: YesSubject: search.filters.subject.MYCOBACTERIUM TUBERCULOSIS

Search Results

Now showing 1 - 2 of 2
  • No Thumbnail Available
    Item
    100 AÑOS DESPUÉS DE LA BCG, VACUNAS VIVAS ATENUADAS FRENTE A LA TUBERCULOSIS
    (Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Medicina, 2024-09-24) Freire-Bravo, Milena Thais; Echeverría Valencia, Gabriela Fernanda
    Background: For more than a century, the BCG vaccine, derived from an attenuated strain of Mycobacterium bovis known as bacillus Calmette-Guérin, has been used to prevent tuberculosis (TB). Despite its widespread use, the effectiveness of the BCG vaccine is variable, and its protection is transitory. Objective: To compile information on the feasibility and effectiveness of new live attenuated vaccines as alternatives to the BCG vaccine in the prevention of tuberculosis. Methods: A bibliographic review of descriptive scope was carried out, using articles specialized in medical, nursing and epidemiology topics from the last two years (2022-2023), the search was carried out autonomously in various databases. Results: In clinical trials and preclinical studies, various live attenuated, inactivated and subunit/adjuvant vaccines have shown potential to improve immunogenicity and protection against tuberculosis. Vaccines such as MTBVAC and RUTI are in different phases of clinical development, while others, such as M72/AS01E and H56, are in advanced phases of testing. Conclusions: The invasion of M. tuberculosis can culminate in bacillary dissemination to other vital organs; it is crucial to develop more effective vaccines for adults and optimize vaccine combinations, addressing the genetic variability of the strains and immunological differences between populations. Currently, research into vaccines against tuberculosis reflects notable progress and an increasingly deep understanding of immunological interactions.
  • No Thumbnail Available
    Item
    “Tuberculosis extrapulmonar de localizacion en aparato genital femenino”
    (Universidad Técnica de Ambato - Facultad de Ciencias de la Salud - Carrera de Medicina, 2018-06-01) Sisa Sizalema, Verónica Elizabeth; Gavilanes Sáenz, Víctor Patricio Dr. Esp.
    Tuberculosis is considered a major health problem worldwide, since it affects about 9.4 million people each year and has around two million deaths. Extrapulmonary tuberculosis (TB) is a pathology caused by the agent Mycobacterium tuberculosis (MT), which can affect any organ of the human body, mostly appears as a spread of a pulmonary focus and which is facilitated in patients with conditions of immunosuppression. The present case is about a 60-year-old patient with no relevant medical history, who is referred from the health center due to abundant postmenopausal vaginal bleeding, accompanied by abdominal pain of several months, which is why xiv external examinations are performed of laboratory of images and the stain of Ziehl-Neelsen in secretion of cervix that reports positive for tuberculosis, for that reason it is contrarefiere to the health center where it is realizing the scheme of treatment.