EFECTO DE LOS MEDICAMENTOS ANTIINFLAMATORIOS NO ESTEROIDEOS (AINES) EN LA CONSOLIDACIÓN ÓSEA

Abstract

Introduction: Bone consolidation is the regeneration process after a fracture, this occurs in 3 phases, the first being the inflammatory and proliferative phase, followed by the formation of the fracture callus and finally the remodeling, however, this process generates pain, inflammation, fever, swelling and redness, so non-steroidal anti-inflammatory drugs (NSAIDs) are used for their treatment; however, in humans some studies have identified that these drugs can slow bone consolidation. Objective: To describe that the use of NSAIDs (non-steroidal anti-inflammatory drugs NSAIDs) can prolong the healing time of fractures through a systematic review and thus be able to establish the effectiveness and safety of the use of NSAIDs. Methodology: Documentary review of scientific articles published from January 2018 to June 2023, which had the online databases PubMed, Scielo and ScienceDirect as search tools, in addition, the method used focused on complying with most of the sections of the PRISMA 2020 declaration. Results: A total of 788 initial articles were collected, of which only 12 that met the inclusion requirem ents were selected. Conclusion: It has been determined that the use of NSAIDs in fractures is directly involved in the delay of consolidation, because it affects the formation of colonies of human skeletal stem cells, the osteoblast and its bone - forming capacity.