POLIOVIRUS: UNA ACTUALIZACIÓN EN EL ESQUEMA DE VACUNAS

Abstract

Polio, caused by the poliovirus, has been a pivotal target in the global eradication of infectious diseases. Vaccination programs have played a fundamental role in combating this disease, and various immunization strategies have been developed over time. One of these strategies is the combination of sequential inactivated polio vaccines (IPV) and oral polio vaccines (OPV) against the poliovirus. The aim of this literature review was to analyze the available literature on the effectiveness and safety of the combination of IPV and OPV in polio vaccination schemes. The methodology employed is based on the compilation and analysis of previous studies, scientific articles, and clinical trial data related to this strategy. The results of the review suggest that the combination of IPV and OPV can be effective in protecting against the poliovirus. This strategy has shown to enhance immunogenicity, particularly concerning serotype 2 of the poliovirus, and reduce risks associated with OPV, such as vaccine-associated paralytic polio (VAPP). In conclusion, the combination of IPV and OPV in polio vaccination schemes is a promising strategy that can significantly contribute to the eradication of the disease. However, it is crucial to maintain constant monitoring and rigorous evaluation to ensure its long-term effectiveness and safety. This review underscores the importance of considering this strategy in vaccination programs to achieve the goal of a polio-free world more effectively.