Propuesta de una quimioteca de compuestos relacionados estructuralmente y diseñados para el tratamiento la enfermedad de Huntington

Abstract

Huntington's disease (HD) is an inherited neurodegenerative disorder that affects movement, cognition and behaviour. It is characterised by uncontrollable chorea movements, difficulty speaking and swallowing, memory and thinking problems, and mood swings. HD progresses over time and usually results in death 15-20 years after diagnosis; treatment focuses on controlling symptoms. Medications can help relieve chorea movements, muscle stiffness and psychiatric problems. Physiotherapy and speech therapy may also be helpful. Research into HD is ongoing, with the goal of finding new therapies and, ultimately, a cure. Scientists are using various methods, such as bioinformatics and computer science, to identify genes and proteins that may be involved in the disease. In this study, these methods were used to identify 20 elite genes potentially implicated in HD. The researchers also identified several promising therapeutic targets, including DRD2, PDE10A and CNR1. These findings provide new insights into the molecular basis of HD and may lead to the development of new treatments. HD research is encouraging and there is steady progress towards understanding and treating this devastating disease. Scientists are working hard to find a cure, and with continued support, it is hoped that one day this goal will be achieved.