Principales factores relacionados a la esteatohepatitis no alcohólica y su progresión a hepatopatía crónica

Abstract

Non-alcoholic steatohepatitis (NASH) is the accumulation of fat in the liver causing inflammation in the liver tissue, very common in the population, caused by variousfactors such as genetic, environmental, and related to lifestyle, currently its incidence has been increasing rapidly, not being detected in a timely manner can progress to chronic liver disease. NASH is caused by the excessive accumulation of triglycerides, which in turn are responsible for generating lipotoxicity and oxidative stress due to previous persistent hepatic steatosis. His clinic is very unspecific at the time of questioning or physical examination performed. The diagnosis of NASH is usually detected as incidental findings in which we observe increased transaminases or the presence of fatty tissue on ultrasound. There are scores that help us to diagnose it, however, the Gold standard is the biopsy, but it is not recommended because it is an invasive method which can bring future complications to the patient. The main treatment is non-pharmacological, making resounding changes in the patient's lifestyle, opting for a healthier style that includes a good diet and physical exercise, allowing the improvement of inflamed liver tissue and avoiding possible complications such as cardiovascular ones, which are very common. . Pharmacological treatment will be chosen as long as non-pharmacological treatment fails, such as vitamin E and pioglitazone, which helps us reduce the risk of developing fibros.