Ciencias de la Salud

URI permanente para esta comunidadhttp://repositorio.uta.edu.ec/handle/123456789/813

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Autor/a: search.filters.author.Bonilla Fernández, Solange AracelyTema: search.filters.subject.COMORBILIDADES

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    FACTORES DE RIESGO Y ENFERMEDADES SISTÉMICAS ASOCIADAS A LA ENFERMEDAD DE PEYRONIE: UNA REVISIÓN BIBLIOGRÁFICA
    (2025-10-15)
    Bonilla Fernández, Solange Aracely
    ;
    Loaiza Merino, Iván Patricio
    ;
    Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Medicina
    Introduction: Peyronie's disease (PD) is a connective tissue disorder that affects the tunica albuginea of the penis, causing a fibrous plaque that can generate deformities, pain and erectile dysfunction, affecting men between 45 and 60 years of age. Objective: To conduct research on risk factors and systemic diseases related to peyronie's disease, identifying risk factors for its development in order to improve the quality of life of patients and highlight the importance of early detection. Methods: Bibliographic review of clinical trials, meta-analysis and descriptive studies published in the last 5 years in English and Spanish. 131 articles from urological journals worldwide such as Nature, Science, JAMA and databases such as PubMed, Scopus and Web of Science were analyzed. Results: Of the 51 articles selected, no precise data were found in Latin America and Ecuador due to the underdiagnosis of this pathology. Risk factors such as age, smoking, microtrauma and malnutrition increase oxidative stress. Systemic diseases are associated, especially connective tissue, vascular and endocrine diseases. Discussion: Genetic predisposition is a key factor that facilitates microtrauma to initiate fibrosis. Systemic diseases, especially connective tissue and vascular diseases, generate hypoxia and fibrosis in the tunica albuginea. Conclusion: Peyronie's disease affects sexual health by causing curvature and pain in the penis. Its early detection allows effective treatments, improving the physical and emotional well-being of patients.