Browsing by Author "Caicedo Albán, Samantha Lizbeth"

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    Evaluación in silico de la influencia de la heterogeneidad tumoral en la evolución clonal del cáncer de mama
    (Universidad Técnica de Ambato. Facultad de Ciencia e Ingeniería en Alimentos y Biotecnología. Carrera de Biotecnología, 2025-02) Caicedo Albán, Samantha Lizbeth; Galarza Galarza, Cristian Fernando
    The present study seeks to understand the influence of tumor heterogeneity on cancer progression and metastasis development, proposing a starting point for personalized treatment. Data from breast cancer were used, with sequences from samples belonging to primary tumors and tumors in the lymph nodes. Bioinformatics techniques were applied for processing, and differential expression analysis was used to identify genes that were expressed in each of the experimental conditions. Interaction networks were represented to identify the different interactions of elite genes with other genes. The functionality of these genes was validated using the functional enrichment technique to identify the role that these genes play in cell integrity and homeostasis. A search for variants was performed with the selected genes to identify the influence that these genes have on the development and progression of metastasis. Tumor heterogeneity on clonal evolution was evaluated by analyzing the influence of the variants of each type of tumor, observing that GL has a higher incidence on metastasis compared to TP.