Evaluación de la capacidad cicatrizante in vivo de formas farmacéuticas elaboradas con extracto etanólico de hojas de matico (Eupatorium glutinosum)

Abstract

Wounds represent an important cause of morbidity and mortality globally. Despite current options such as dressings and topical medications, a more effective and affordable treatment is being sought. Its approach can be carried out through the alternative use of traditional medicine plants. Matico (Eupatorium glutinosum) has demonstrated antimicrobial and healing properties, suggesting its potential in cosmetic products. However, its stability is compromised by external factors such as humidity and light. Obtaining the extract allowed microencapsulation to be carried out by spray drying with gum arabic and maltodextrin. Two pharmaceutical forms were prepared: a cream and a matico hydrogel. In addition, quality control tests, determinations of phenols, total flavonoids and antioxidant activity were carried out. The wound was treated with the pharmaceutical forms and the extract in 5 experimental groups for 14 days. In the in vivo test, the healing capacity of the 5 experimental groups was evaluated, where the group of rats (Rattus norvergicus) treated with matico cream was identified as the most effective, evidenced by the lowest percentage of the wound area, with 1 .3 percent in the seventh.