Evaluación de la eficiencia de los polímeros Eudragit® en la microencapsulación de pamoato de praziquantel mediante secado por aspersión

Abstract

Helminthic infections are currently one of the leading causes of morbidity, and they can be treated with antiparasitics that are effective for both humans and animals. Praziquantel stands out among them as a first-line medication, but it has several disadvantages like a bad taste and limited absorption. As a result, methods for protecting the active pharmaceutical ingredient and masking the taste have been needed to minimize the incidence of infections and enhance the administration and measurement of the medication. To do this, spray drying solutions made of various drug-polymer ratios were used to microencapsulate praziquantel with the use of Eudragit® polymers as a masking agent. The various microencapsulated products were also exposed to characterization testing using qualitative and quantitative techniques like Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimetry, and Scanning Electron Microscopy. As a negative control for these tests, praziquantel and the polymer were combined physically to create the combination. Finally, different yields of microencapsulated powders were produced; these yields varied according to the type of polymer and the ratio employed. Out of all of these, polymer L-100 in the 20:80 ratio stood out due to its maximum average yield of 39 percent. Additionally, it was determined by FTIR and DSC analysis that polymer L-100 is the best encapsulating agent, followed by polymer L-100-55 and polymer S-100.