Evaluación de la actividad antiinflamatoria de liposomas obtenidos mediante secado por aspersión a partir del extracto hidrosoluble de la cáscara del coco verde (Cocos nucifera).

Abstract

Anti-inflammatory activity of liposomes obtained was evaluated by spray drying from water-soluble extract of green coconut shell (C. nucifera). The extract concentrated mother 2.82% total solids presented 14416 [mg on dry basis] total polyphenol quantified by the method of Follin- Cioclateu 750 nm. The antiinflammatory activity of the liposome was evaluated in vitro at 450 nm by the method of reduction of tetrazolium salts to salts formazan using the reagent WST-1 on human neutrophils [104 cells / µL] swollen with Zymozan opsonized A, compared to controls Dimethylsulfoxide, Triton X-100 and Aspirin. The encapsulation efficiency of polyphenols in the phospholipid layer infrared spectrophotometry was determined by scanning electron microscopy and; with an average particle size of 2.83 ± 0.942 microns. The anti-inflammatory activity of the liposomes was 58% at a concentration of 200 ppm, higher than those presented by the controls.