Browsing by Author "Valencia Armas, Joselin Gabriela"

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    Análisis de la actividad antiinflamatoria y agregación plaquetaria compuestos bioactivos del extracto etanólico de Cedrón (Aloysia citrodora paláu)
    (Universidad Técnica de Ambato. Facultad de Ciencia e Ingeniería en Alimentos y Biotecnología. Carrera de Biotecnología, 2024-08) Valencia Armas, Joselin Gabriela; Pérez Aldás, Lander Vinicio
    Currently, access to large medical treatments is a global challenge, which drives a renewed interest in traditional medicine and medicinal plants, however, the lack of scientific studies limits their acceptance in public health. This research analyzes the bioactive compounds of the ethanolic extract of cedron (Aloysia citrodora Paláu) for its anti-inflammatory and antiplatelet aggregation activity. The cedron plant, also known as verbena, confers a range of therapeutic uses including the reduction of inflammation and protection against oxidative stress. Wherein, gallic acid reduces inflammation, while quercetin exhibits anticoagulant properties. The extraction yield was 17.01 percent, and the content of total phenols and flavonoids was found to decrease as the extract was diluted, with maximum values of 163.45 milligram (mg) over gram (g) and 99.12 mg over g, respectively, at the highest concentration. In terms of anti-inflammatory activity, the cedron extract showed an inhibition of albumin denaturation of 61.85 percent, lower than diclofenac (95.1 percent), but comparable as it is diluted. In addition, the extract inhibited platelet aggregation similarly to the control drug at all concentrations tested. The flavonoids and phenols present in the ethanolic extract of cedron exhibit significant anti-inflammatory and antiplatelet aggregation activity, standing out as a natural alternative. These findings contribute to the development of new organic products and to the growth of the Flor Andina company.