Browsing by Author "Morillo Perugachi, Edison Wladimir"

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    ENTEROBACTERIACEAE PRODUCTORAS DE CARBAPENEMASAS EN PACIENTES HOSPITALIZADOS EN EL HOSPITAL DE ESPECIALIDADES FUERZAS ARMADAS NO.1.
    (2024-11-08) Morillo Perugachi, Edison Wladimir; Poveda Paredes, Francisco Xavier; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Centro de Posgrados
    Carbapenemase-producing Enterobacterales represent a global health problem since therapeutic possibilities are almost nil. Carbapenems are the last step in the treatment of bacterial infections, resistance to these has managed to put the scientific communities in check in search of new drugs as well as achieving an effective identification, the spread of this class of bacteria in hospital environments has caused patients to be associated with higher statistics of morbidity, mortality, hospital stay and high economic costs. To identify carbapenemase-producing Enterobacteriaceae in patients hospitalized at the Armed Forces Specialty Hospital No. 1. It is of an observational descriptive type, since it improved the identification by giving an algorithm in the face of the suspicion of enterobacteriaceae with resistance to carbapenems from a result provided by the automated Vitek®2 equipment by micro dilution obtaining data with the minimum inhibitory concentration and phenotypic methods, all of these were correlated with the desire to provide more information on other antimicrobial agents other than beta-lactams with the epidemiological booklet. Fourteen isolates of Enterobacteriaceae strains were described with phenotypic determination of KPC type carbapenemase, following algorithms of automated methods in Vitek®2 and phenotypic methods such as the Inhibition synergy test with disks such as phenyl boronic acid (PBA) for serine betalactamase type Enterobacteriaceae and the ethylenediaminetetraacetic acid (EDTA) disk for metallo beta-lactamase type Enterobacteriaceae, modified carbapenem inactivation method (m CIM) and immunochromatography for the detection of OXA-48, KPC, NDM, IMP VIM carbapenemases. It was possible to identify 14 enterobacteriaceae producing KPC-type carbapenemases following a detection algorithm in which the automated Vitek®2 method was detailed with the respective analysis of the interpretation of the antibiogram with the minimum inhibitory concentrations of the carbapenems as well as the phenotypic methods of the Synergy Inhibition Test with disks, modified method of carbapenem inactivation and immunochromatography.