Browsing by Author "Morales Ulloa, Cristopher Ismael"

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    BIOMARCADORES SANGUÍNEOS EN LA ENFERMEDAD DE ALZHEIMER. UNA REVISIÓN BIBLIOGRÁFICA
    (2025-02-25) Morales Ulloa, Cristopher Ismael; Guangasig Toapanta, Víctor Hernán; Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Laboratorio Clínico
    Alzheimer's disease (AD), is the leading cause of dementia in those over 65 years of age and responsible for 50-60% of global cases, its definitive diagnosis is by tests that identify amyloid-β (Aβ) plaques and tau tangles in the brain. However, the use of these tests is limited due to their invasive nature and high cost. This study is based on a descriptive investigation of literature documents with a retrospective analysis. For the collection of information, various databases such as PudMED, Scielo, Scopus were consulted. During the bibliographic search, 16 articles related to the subject of the study were found, for which the PRISMA methodology was used. This article analyzes the usefulness and reliability of blood biomarkers for Alzheimer's disease in its different stages. It points out the need to improve some markers such as Aβ42/Aβ40 assays and the accuracy of different forms of p-tau. In addition, it explores other promising biomarkers such as neurofilament light (NfL), GFAP and synaptic markers. The article emphasizes the importance of further research to develop more robust tests to match the efficacy of cerebrospinal fluid (CSF) biomarkers and positron emission tomography (PET).