Browsing by Author "Maridueña Paredes, Lizbeth Sarahi"

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    ASOCIACIÓN ENTRE LA COMPOSICIÓN DE LA MICROBIOTA INTESTINAL: RELACIÓN CON LA ENFERMEDAD CELIACA Y DESNUTRICIÓN
    (2025-06-19) Maridueña Paredes, Lizbeth Sarahi; Torres Torres, Johny Mauricio; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Medicina
    The aim was to determine the association between the composition of the intestinal microbiota and its relationship with celiac disease and malnutrition. A systematic review was carried out following the PRISMA guidelines, using databases such as PubMed, Dialnet, Google Scholar, SciELO and Elsevier. Studies published between 2020 and 2024 in Spanish and English, which analysed the composition of the intestinal microbiota in patients with celiac disease, were included. The selection of studies was carried out through a threephase process: review of titles and abstracts, evaluation of the full text and final data extraction. The results revealed an intestinal dysbiosis characterised by a significant reduction in beneficial bacteria (Bifidobacterium and Lactobacillus) and an increase in potentially pathogenic bacteria (Bacteroides and Escherichia coli). These microbial alterations are not only a consequence of celiac disease, but play a fundamental role in its development. Microbial changes were identified up to 18 months before clinical manifestation, suggesting their potential as an early biomarker. Factors such as antibiotic use, birth route and type of feeding significantly influence the composition of the microbiota. In conclusion, the intestinal microbiota plays a crucial role in the pathogenesis of celiac disease and malnutrition. Microbial alterations compromise nutrient absorption, modify the immune response and affect intestinal permeability. Emerging therapeutic strategies focus on microbiota modulation through probiotics, prebiotics and fecal microbiota transplantation, representing a promising approach for the management of these conditions.