Browsing by Author "Maldonado Freire, Sofía Antonella"

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    EVALUACIÓN DE LA ACTIVIDAD ANTIBIOFILM DE ACEITES ESENCIALES FRENTE A CEPAS ATCC BACTERIANAS
    (2025-02-24) Maldonado Freire, Sofía Antonella; Vicalcundo Córdova, Mario Fernando; Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Laboratorio Clínico
    The increase in multidrug-resistant (MDR) microorganisms and the formation of biofilms as a pathogenicity mechanism represent serious challenges to public health, increasing morbidity and mortality in healthcare-associated infections (HAIs). To address this issue, the present study evaluated the antibiofilm activity of essential oils from Rosmarinus officinalis, Cymbopogon citratus, and Anethum graveolens against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853. The results showed that the essential oils significantly inhibited biofilm formation, achieving efficacy rates of up to 99.74% in S. aureus, 92.34% in E. coli, and limited activity against P. aeruginosa, which exhibited greater resistance due to its complex cellular structure. Notably, C. citratus proved to be the most effective against all strains analyzed, followed by A. graveolens and R. officinalis. These findings highlight the potential of ethanolic extracts as antibiofilm agents by interfering with initial bacterial adhesion and quorum sensing communication systems. Therefore, this research reinforces the therapeutic value of essential oils as a promising alternative to combat antimicrobial resistance, providing a scientific basis for future vivo applications.