Alteraciones del perfil lipídico como factor de riesgo de insulinoresistencia en adolescentes con sobrepeso y obesidad

Abstract

Measurement of HOMA-IR is considered a vitally important test in the diagnosis and monitoring of insulin resistance. Previous studies have shown that alterations in weight, lipid profile and insulin can raise HOMA-IR concentrations independently of the patient's glycaemic status. Therefore, the aim of this study was to relate alterations in the lipid profile as a risk factor for the development of insulin resistance in overweight and obese adolescents aged 10 to 15 years, from the "La Providencia" Educational Unit, through the clinical determination of insulin, glucose, triglycerides, fasting cholesterol and HOMA-IR, obtaining as a result that 13 people with normal weight, of whom 11 women and 2 men presented altered concentrations of HOMAIR, Despite having a healthy glycaemia and lipid profile, in the pathological population (overweight and obesity), it was found that 27 people presented high concentrations of the HOMA index, divided into 17 women and 10 men, in which a slight alteration in their cholesterol, triglycerides or both was observed, so that in this study a relationship was found to exist between the alterations in the lipid profile values and the HOMAIR.