Potencial terapéutico de bacteriófagos frente a Staphylococcus Aureus resistente a Meticilina

Abstract

Antimicrobial resistance is a phenomenon in which microorganisms such as bacteria become resistant to drugs that were previously effective in eliminating them or controlling their growth. According to WHO one of the priority pathogens in need of a therapeutic alternative is methicillin-resistant Staphylococcus aureus (MRSA), due to its large number of pathogenicity mechanisms, its ability to synthesize biofilms and its particularity of clonal variation to expand and colonize new media. Bacteriophage therapy has shown a broad approach to treat infections caused by this pathogen, given its high specificity and effectiveness in killing the host bacterium. However, there are still some obstacles to its therapeutic use in humans, and further clinical trials are required. This research article details cases and clinical studies that provide useful information that can be used in further clinical studies.