Marcadores serológicos asociados al mal pronóstico en pacientes Covid-19 positivos

Abstract

Background: Covid-19 is a disease caused by a new coronavirus known as SARS-CoV-2. Spike viral protein binds to ACE2 body receptors and determines its infectivity. This process has many effects on the host, causing damage to the respiratory system and at the systemic level in general, evidenced in the elevation of laboratory markers such as Interleukin-6, Ferritin and D-Dimer. Objective: To analyze biomarkers: Interleukin-6, Ferritin and D-Dimer as factors of poor prognosis in Covid-19. Methods: The data was collected from Covid-19 patients who also had results of IL-6, D-D and Ferritin obtained through the IESS Ambato hospital databases. Findings: We reported 114 Covid-19 patients, whom we analyzed serological markers. D-D and IL-6 show a 1.34 OR (C.I.: 1.14 - 1.58) and 1.26 OR (C.I.: 1.11 - 1.43) respectively. Ferritin had a positive association in female population 1.11 OR (C.I.: 0.99 – 1.24), but in the male population, we didn’t find a significant association 3.91 OR (C.I.: 0.46 - 32.99). It was found that comorbidities were a protective factor with a negative association of 0.88 OR. Secondary causes of death in Covid-19 patients were cardiac arrest and pneumonia (23.1%). Conclusion: IL-6, Ferritin and D-D markers were evaluated and proved valuable tools to predict poor prognosis in patients with Covid-19. These markers proceeded independently of other factors like comorbidities. The findings of this study may help manage other pathologies with a similar curse and to focus more on the importance at the laboratory level as a prognostic support.