“Artritis reumatoide seronegativa en paciente con complicación séptica pulmonar.”

Abstract

Rheumatoid arthritis is a systemic, chronic disease characterized mainly by inflammation of the joints, producing pain, deformity and difficulty in movement, although it can also affect other parts of the body, presenting extra-articular manifestations. The cytokines act as soluble mediators responsible for the inflammatory process, affecting, mainly the synovial membrane of the joints, with an estimated prevalence of 0.5-1% of the world population. The onset of the disease is usually insidious, with the predominant symptoms of pain, stiffness and joint edema. The early use of medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, disease modifying drugs and tumor necrosis factor inhibitors can significantly change the clinical course of RA, thus preventing joint damage and disability. It presents a low frequency of spontaneous healing, with an optimal treatment a good control of the disease is achieved in most cases.