Evaluación de polímeros Eudragit en la microencapsulación de Diclofenaco de sodio (DCS) mediante secado por aspersión

Abstract

The purpose of this research was to evaluate Eudragit® S100, Eudragit® L100 and Eudragit® L100-55 polymers in the Diclofenac Sodium (DCS) microencapsulation. The DCS is a non-steroidal anti - inflammatory drug that has analgesic properties whose regular treatment leads to the appearance of gastric lesions. The current study consisted on preparing DCS microspheres by using the spray drying method, with an inlet and outlet temperature of 150 and 85 ° C respectively and a drug-polymer ratio of 1: 3. The microparticles obtained were evaluated by determining the yield and microencapsulation efficiency. For qualitative characterization of the microgranules , Differential Scanning Calorimetry (DSC) was performed. Such microspheres were also subjected to scanning electron microscopy (SEM) to obtain morphological characterization and particle size. The microparticles prepared with Eudragit® S100, Eudragit® L100 and Eudragit® L100-55 presented yields of 71.742±0.068 %, 73.712± 0.146 % and 55.530 ± 0.097 %; and a microencapsulation efficiency of 81.4 ± 0.223 %, 67.80± 0.506 % and 65.65 ± 0.180 % respectively. The study revealed that the best formulation was achieved by using Eudragit® S100; DCS microencapsulated thermograms showed the disappearance of the melting peak of DCS pure. The average size of the microparticles was 3.93 ± 1.87 microns, with a spherical shape with a regular surface, suitable for masking DCS.