“Relación entre los biomarcadores de daño hepático tgo, tgp, ggt, no y los polimorfismos genéticos rs671, rs1800497, rs1229984 asociados a la predisposición de padecer alcoholismo en la población de la provincia de Tungurahua.”

Abstract

Alcoholism is a very serious problem of public health, significantly affects the quality of life of people. Studies indicate that polymorphisms present in the ADH, ALDH, ANKK1 genes increase susceptibility to developing liver disease, evaluated by determining different markers as SGOT, SGPT, GGT and NO. This research is part of the project entitled "GENETIC MARKERS ASSOCIATED WITH THE WILLINGNESS OF ALCOHOLISM IN TUNGURAHUA PROVINCE" and aims to establish the correlation between biomarkers (SGOT, SGPT, GGT), NO and genetic polymorphisms rs671, rs1800497 , rs1229984 associated with the predisposition of developing alcoholism in the population of the province of Tungurahua. The serum levels of the enzymes (TGO, TGP, GGT) and NO were analyzed in 40 people from 18 to 79 years of age. For analysis of the samples the kinetic method (enzymes) and Griess

method (NO) it was applied. 100% of controls have normal enzyme values (SGOT, SGPT, GGT) and low values of NO, in the case group 4% have increased levels of TGP, 12% TGO, 16% GGT and NO levels of 122 to 163.9μM. 96% of cases present the G/G genotype predisposing Gene ADH, the G / A genotype of ALDH gene is present in the same percentage in both cases as controls and 78% of the population have the genotype A + (A1 / A2, A1 / A1) predisposing to alcohol gene ANKK1.

ANOVA statistical analysis showed a value of p> 0.05 indicates that there is no significant correlation between the levels of the analyzed enzyme (SGOT, SGPT, GGT), NO and genetic polymorphisms rs671, rs1800497, rs1229984 associated with predisposition of developing alcoholism