“Determinación de cistatina c e identificación de la relación con la creatinina sérica en el diagnóstico de insuficiencia renal en pacientes con diabetes mellitus tipo 2”.

Abstract

The present research project has as main objective to determine the Cystatin C and to identify the existing relation with the serum Creatinine to diagnose Renal Insufficiency in patients with Type 2 Diabetes Mellitus. The study was performed with the participation of 30 patients who attend the Diabetic Club of the Pelileo Basic Hospital. Glucose levels were determined by observing that 73% of the population presented hyperglycemia and blood was drawn to determine serum creatinine and Cystatin C, and GFR was estimated by applying two fórmulas (MDRD-4 and Larson), observing that estimated GFR from Creatinine was decreased in 100% of the population while GFR evaluated from Cystatin C was found to be normal in 50%. With estimated GFR, the patients were grouped according to the stage of renal disease in which they were found. In this way, it was observed that serum Creatinine categorized patients into only three stages: moderate, severe and terminal renal damage; while with Cystatin C it was possible to categorize and effectively differentiate disease stages by categorizing the 5 disease stages (normal, mild, moderate, severe and advanced). By means of the Chi-square test, we can verify that the variables have a positive correlation, so we accept the alternative hypothesis that mentions "if there is a relationship between serum Creatinine and Cystatin C for the diagnosis of renal failure", therefore The determination of Cystatin C is a great help in measuring GFR and determining the stage of renal damage.