Evaluación de polímeros Eudragit en la microencapsulación de Ibuprofeno mediante secado por aspersión

Abstract

The unpleasant perception characteristic of the active substance dosage forms such as nonsteroidal anti-inflammatory drugs (NSAIDs), particularly ibuprofen, has become a critical parameter in its development. The method of microencapsulation by spray drying ensures neutralization of the bad taste of the drug. The aim of this research was to microencapsulate ibuprofen with Eudragit® S -100, Eudragit® L -100 and Eudragit® L - 100-55 polymers by spray drying, which was showed by Differential Scanning Calorimetry (DSC) and x-Ray diffractometry (XRD). Using proportions 1: 1.8, drug - polymer dispersions, yields and microencapsulation efficiencies were determined with inlet and outlet temperatures of 150 and 85 ° C respectively in a mini spray dryer, having the best results with Eudragit® S - 100 polymer that presented a yield of 90.180 ± 1.452 % and an efficiency of 57.762 ± 0.462 microencapsulation %. Using a scanning electron microscope, it was shown that the obtained microparticles were spherical, smooth, compact and without pores, thereby preventing contact of the drug with the environment as it can be decomposed in presence of light and avoiding any reaction with atmospheric CO2. Moreover, the size distribution of the microspheres was evaluated, and the average value was 3.8315 ± 1.761 um.