Microencapsulación de doxiciclina mediante secado por aspersión

Abstract

Doxycycline is an antibiotic used to treat diseases such as rickettsiosis, pneumonia, Lyme disease, among others, therefore its conservation has been of great importance, being microencapsulation one of the most used methods. In this case, for microencapsulation as microencapsulating agent, a mixture of polymers constituted by maltodextrin - gum arabic was prepared, where a yield of 86.4 percent was obtained, while with chitosan lactate a yield of 32.2 percent was obtained, besides a color change to grayish brown, the evaluation of the microencapsulation yield was done qualitatively by the method of Fourier Transform Infrared Spectroscopy, This method generates a fingerprint that presents each biological sample, on the other hand, by means of Differential Scanning Calorimetry (DSC), the efficiency of microencapsulation was verified, where it was observed that the reading of the microencapsulated resembles the polymeric mixture, which indicates that it is microencapsulated and the physical mixture that resembles doxycycline has a slight melting peak because it is not microencapsulated.