“Valores de referencia de perfil hepático y lipídico en personas que viven a 3000 metros sobre el nivel del mar”

Abstract

It is essential to determine the reference values of each population, which is the responsibility of local clinical laboratories, through the application of the procedure recommended by the International Federation of Clinical Chemistry and Laboratory (IFCC) and other international institutions such as the Latin American Confederation of Clinical Biochemistry (COLABIOCLI), Spanish Society of Laboratory Medicine (SEQC), etc. However, in practice it is not very common to obtain proper reference values, due to the difficulty in defining and including individuals with similar characteristics, even influencing the large number of patients required for this, which is why the use of the information provided by the manufacturers of the reagents (inserts) is recommended. However, currently prominent national and international professionals propose the harmonization of clinical laboratories, which is defined as the ability to produce comparable information on the health status of the patient regardless of the laboratory that generated the information, for the purpose of the global interchangeability of biological reference values. On the other hand, in the UNE-EN ISO 15189: 2012 standard it mentions that the biological reference intervals must be periodically reviewed and a review of the biological reference intervals must also be made when the laboratory changes an analytical or pre-analytical procedure, this allows to standardize the criteria for obtaining reference ranges in different regions. The global standardization (harmonization) of the inclusion criteria for studies of reference values can be difficult due to differences in population, genetics, environment, physics, lifestyles, etc.