Desarrollo de un gel cosmético antiacné a partir de extracto etanólicode propóleo rico en flavoniodes

Abstract

An ethanolic extract of propolis rich in flavonoids was obtained with a process of alcoholic maceration. Taking into account factors such as ethanol concentration, resting time and agitation time. Flavonoids have many benefits for skin care as they are antioxidant, healing, anti-inflammatory and antimicrobial substances, which is why they are of great interest for the cosmetics industry. After obtaining the ethanolic extract of propolis, the flavonoid concentration was evaluated in the extract samples, applying a complete factorial experimental design 23 with two replicas, this analysis determined which is the best interaction of the study factors to obtain a higher concentration of flavonoids, the amount of flavonoids was assessed by uv spectrophotometry, with the preparation of a calibration curve with quercetin and obtaining the absorbances of the samples. Subsequently, the concentration of flavonoids expressed in liquid base was calculated as mg per ml of quercetin, where it was obtained that the AC treatment, that is to say the 96 percent ethanol combination, the rest time of 21 days and a daily agitation of 30 minutes in the maceration process obtaining 5.38 more less 0.01 flavonoids. This extract was used for the formulation of the anti-acne cosmetic gel analyzing the compatibility with other excipients. The analysis of stability and quality control of the finished product was carried out so that the company LabGénesis could obtain the health notification and be able to make its commercialization.