Obtención de un ingrediente activo microencapsulado con propiedades antiinflamatorias a partir de 8 plantas medicinales

Abstract

The use of medicinal plants for its great availability and variety of active ingredients with pharmacological importance has been a source of research for scientific advances. The present study focused on obtaining an active anti-inflammatory ingredient from the ethanolic extracts of 8 medicinal plants: Cymbopogon citratus, Mentha sativa L, Cynara scolymus L, Zingiber officinale L, Ocimum basilicum L, Cinnamomum verum J and Camellia sinensis. The best conditions for the extraction process of the plant metabolites of the plants used were established from a factorial design 22, using two study variables, the solvent ethanol concentration (ETOH) and the extraction time, using the technology of spray drying the ethanolic extracts were microencapsulated. For the determination of the anti-inflammatory activity, it was subjected to in vitro tests by means of the method of membrane stabilization of human erythrocytes compared to the anti-inflammatory control used with aspirin. Identifying that the highest percentage of anti-inflammatory activity is possessed by microencapsulation from the mixture of the 8 medicinal plants with a value of 76, 96 percent. Using ultraviolet-visible spectrophotometry, two phytochemical components were quantified that give the anti-inflammatory capacity to microencapsulation: total polyphenols 93.50 more less 1.78 mg AG / g microencapsulated and total flavonoids 54.80 more less 8.61 mg quercetin / microencapsulation g. This research showed a synergistic effect of the mixture of the 8 plants due to the potentiation of the activity of the active ingredients that give them the anti-inflammatory capacity (polyphenols and flavonoids).