Medicina
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Item “Complicaciones articulares en pacientes con artritis reumatoide”(Universidad Técnica de Ambato - Facultad de Ciencias de la Salud - Carrera de Medicina, 2017-02-01) Cunuhay Lozano, Alejandra Lizbeth; Morocho Llanos, Domingo Dr.Rheumatoid arthritis chronic systemic inflammatory disease, and autoimmune multifactorial cause, is characterized by pain and progressive joint damage disabilities. It affects 1% of the world population, is more prevalent in women than in men (3: 1), occurs most often between 30 and 60 years old. Typical symptoms include joint pain predominantly at night and morning, morning stiffness of joints for more than 15 minutes, swollen joints, typically the metacarpophalangeal joints, and proximal interphalangeal joints. General ill feeling. In the initial stage are affected a few joints, then polyarthritis develops. Diagnosis depends on the characteristics clinical alterations. The presence of morning stiffness or casual observation of subcutaneous nodules, the presence of rheumatoid factor, liquid inflammatory synovial and radiographic abnormalities bone demineralization and erosions in the affected joints, elevated erythrocyte sedimentation rate, the diagnosis is based on criteria American Rheumatism Association constituting a useful guide for diagnosis. Treatment is aimed at controlling the inflammatory activity, prevent the progression of structural joint damage. NSAIDs provide symptomatic relief, its effectiveness is only marginal, so that the treatment of this disease is based on the use of so-called modifying antirheumatic drugs disease. These agents have shown unique ability to act against different manifestations. There are two main groups of drugs that meet these characteristics: traditional DMARDs and biologic therapies called. The former are a group of small molecule chemical synthesis, whose mechanism of action is poorly defined sometimes or act against a specific therapeutic target involved in the pathogenic process of immune response. Biological therapies are products used in the treatment made from cultured cells of cell banks disease, these therapies have been designed so that act specifically against a therapeutic target.