Browsing by Author "Tirado Poveda, Hugo Marcelo"
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Item Evaluación de la actividad antiinflamatoria de liposomas obtenidos mediante secado por aspersión a partir del extracto hidrosoluble de la cáscara del coco verde (Cocos nucifera).(Universidad Técnica de Ambato. Facultad de Ciencia e Ingeniería en Alimentos. Carrera de Ingeniería Bioquímica, 2016-06) Tirado Poveda, Hugo Marcelo; López Hernández, Orestes DaríoAnti-inflammatory activity of liposomes obtained was evaluated by spray drying from water-soluble extract of green coconut shell (C. nucifera). The extract concentrated mother 2.82% total solids presented 14416 [mg on dry basis] total polyphenol quantified by the method of Follin- Cioclateu 750 nm. The antiinflammatory activity of the liposome was evaluated in vitro at 450 nm by the method of reduction of tetrazolium salts to salts formazan using the reagent WST-1 on human neutrophils [104 cells / µL] swollen with Zymozan opsonized A, compared to controls Dimethylsulfoxide, Triton X-100 and Aspirin. The encapsulation efficiency of polyphenols in the phospholipid layer infrared spectrophotometry was determined by scanning electron microscopy and; with an average particle size of 2.83 ± 0.942 microns. The anti-inflammatory activity of the liposomes was 58% at a concentration of 200 ppm, higher than those presented by the controls.Item Evaluación de la cinética de adsorción de fluoruro de agua natural mediante un lecho fluidizado de hidroxiapatita de calcio(Universidad Técnica de Ambato. Facultad de Ingeniería en Sistemas, Electrónica e Industrial. Maestría en Química, 2021) Tirado Poveda, Hugo Marcelo; Córdova Suárez, Manolo AlexanderEXECUTIVE SUMMARY A fluidized bed with calcium hydroxyapatite (Ca10(PO4)6(OH)2) has been designed to reduce the concentration of fluorides in the natural water of the Totoras sector where fluoride concentrations in natural water exceed on average 3 mg/L F-, through the principle of ion exchange, the kinetics of fluoride adsorption on the solid matrix of commercial PAH was determined following an experimental design 2 at k=3, where by means of the response optimization analysis, the best treatment conditions were identified with a result of 0,83 ± 0, 02 mg/L F- of adsorbate in solution, after three days of treatment with a PAH load of 70 percent or 63 kg at a constant water flow of 2 L/min, indicating a maximum removal efficiency of 75.77 perecent, for which this treatment was adjusted to the linear model of the Langmuir Isotherm to be able to scale up the process to higher flow rates, For this purpose, the linear parameters of the Langmuir model were obtained with values of qmax of 1.15 mg of adsorbate per kg of adsorbent for a binding factor K of 2,76 liters of solution per kilogram of adsorbent.