Browsing by Author "Peñafiel Canseco Fabian Alejandro"

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    ACTUALIZACIÓN DE LA REVISIÓN BIBLIOGRÁFICA DE LA INMUNOTERAPIA EN LEUCEMIA MIELOIDE AGUDA
    (2025-06-16) Peñafiel Canseco Fabian Alejandro; Cruz Castillo Yessenia Magaly; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Medicina
    Introduction: Acute myeloid leukaemia (AML) is a haematological disease characterised by uncontrolled proliferation of immature cells in the bone marrow, interfering with normal blood cell production. Despite advances in chemotherapy and bone marrow transplantation, relapse and mortality rates remain high. In this context, immunotherapies have emerged as an innovative and promising strategy. Aims: This article aims to describe therapeutic advances in immunotherapy for AML, analysing the clinical outcomes and survival rates of these patients treated with immunotherapy. Material and methods: A literature review was carried out including articles from the last 5 years retrieved from scientific databases such as Scopus, PubMed, Science Direct and Springer. Scientific articles referring patients with other types of leukaemia and which have been treated with phytotherapy and gene therapies were excluded.Keywords: acute myeloid leukaemia; treatment; immunotherapy. Results: Different immunotherapy strategies have been reviewed including monoclonal antibodies, immune checkpoint inhibitors, CAR-T cells and therapeutic vaccines that aim to boost the immune system's ability to identify and destroy leukaemic cells, reducing side effects compared to conventional treatments. Conclusions: Against a backdrop of hope and challenges, immunotherapy is emerging as a revolutionary tool that could redefine AML treatment and significantly improve clinical outcomes.