Browsing by Author "Marizande Lozada, María Fernanda"

Now showing 1 - 4 of 4

Factores de riesgo de aparecimiento de complicaciones de las enfermedades hipertensivas en el embarazo en el hospital general Latacunga de madres adolescentes comprendidas entre los 14 – 20 años durante el periodo enero 2010 – enero 2011
(2012-02-15) Marizande Lozada, María Fernanda
Esta constituye una investigación cuali - cuantitativo, documental, descriptivo - retrospectivo, entre enero 2010 – enero 2011, recogiendo los datos de historias clínicas. La población en estudio fueron: pacientes que acudieron al Servicio de Ginecología del HPG “Latacunga” con diagnostico de Enfermedades Hipertensivas del Embarazo. Como resultados se obtuvo: la edad de la mayor parte de pacientes estaban entre los 15 – 20 años; 17 se encuentran en unión libre, 10 eran solteras y 8 estaban casadas, sobre el nivel de escolaridad: 20 de las pacientes a penas habían terminado el nivel primario de instrucción. En los antecedentes obstétricos, 2 del total presentaban antecedentes de gesta previa y fueron bajo peso al nacimiento. En la morbilidad en el embarazo: 7 pacientes presentaban anemia, 2 infecciones de vías urinarias y 1 Hiperémesis gravídica. 46% de las chicas del estudio tuvieron entre 1 – 3 visitas al médico durante su embarazo. La TA al ingreso: 69% de las pacientes tenían TA entre 140/190 – 159/99.
LA RELACIÓN ENTRE LA COMPOSICIÓN DE LA MICROBIOTA INTESTINAL Y SU IMPACTOEN LA SALUD DEL SISTEMA CARDIOVASCULAR: UNA REVISIÓN DE LA LITERATURA
(Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Medicina, 2024-09-24) Checa Garay, Barbara Estefanía; Marizande Lozada, María Fernanda
A narrative review was carried out on the relationship of the intestinal microbiota with cardiovascular diseases. Databases from different articles were used where original studies published between 2019 and 2023 were identified. 20 original studies were reviewed that report that the intestinal microbiota, a diverse set of microorganisms in our gastrointestinal tract, has emerged as a crucial factor in cardiovascular health. Its multifaceted influence is related to metabolic diseases, insulin resistance, obesity and cardiovascular diseases. This complex network of microbial interactions affects immunity,inflammation, and cardiac function. Intestinal dysbiosis, an imbalance in this microbial community, is associated with cardiovascular diseases by influencing risk factors such as diabetes, hypertension and hypercholesterolemia. The review of the literature has made it possible to identify individual variability in the microbiota and the influence of external factors pose challenges in the interpretation of these findings. More research is needed to better understand these complex interactions and optimize specific therapeutic interventions, with attention to safety and effectiveness, as well as personalization of treatments to address individual variations.
REVISIÓN SISTEMÁTICA: ACTUALIZACIÓN DE TERAPIA INTRAARTICULAR EN LAS PATOLOGÍAS TRAUMATOLÓGICAS
(2025-06-16) Solis Cadena, Dayana Monserrath; Marizande Lozada, María Fernanda; Universidad Técnica de Ambato / Facultad de Ciencias de Salud / Carrera de Medicina
Introduction: Traumatologic pathologies such as osteoarthritis (OA) affect a large part of the world's population, especially in developing countries, with predisposing factors such as sedentary lifestyle, obesity and trauma. The prevalence of OA increases with age, being more frequent in people over 60 years of age. In Latin America, the prevalence varies, being 7.4% in Ecuador. Short-term treatment aims to relieve pain and improve function, while long-term treatment attempts to slow disease progression. Intra-articular therapies, such as corticosteroids and platelet-rich plasma, are common options, but their long-term effectiveness is uncertain. Objective: The purpose of this paper is to evaluate recent evidence on the effectiveness of intra-articular therapies in the management of traumatologic pathologies. Materials and Methods: A comprehensive search was conducted in databases such as PubMed, Cochrane Library, and Scopus, including studies in English and Spanish published between 2019 and 2024. 21 studies were selected that met criteria such as use of intraarticular therapies (PRP, HA, corticosteroids, combinations). Results: Plateletrich plasma (PRP) is more effective than hyaluronic acid (HA) and corticosteroids in relieving pain and improving joint function in the long term. HA improves pain and function, but its effect is less than PRP. Corticosteroids offer temporary relief, but with risks of side effects. The combination of PRP and HA shows superior benefits. Mesenchymal stem cells (MSC) promise regenerative effects, but require further studies to confirm their long-term safety and efficacy. Discussion: Intra-articular therapies are a key alternative for patients with trauma pathologies seeking non-surgical options. Although PRP emerges as the most promising treatment, variability in methods and populations studied limits the generalizability of findings. Furthermore, combining therapies might offer a new avenue of management but requires further robust research. Conclusions: PRP stands out as the most effective therapy for pain relief and joint function improvement in trauma pathologies, outperforming HA and corticosteroids. Combinations such as PRP + HA are promising, while mesenchymal stem cells offer an innovative option for the future. However, further studies are needed to confirm these results and ensure long-term safety.
TERAPIA DE CÉLULAS MADRE EN PACIENTES CON PARKINSON
(Universidad Técnica de Ambato/ Facultad de Ciencias de Salud /Carrera de Medicina, 2024-09-25) Pérez Cedeño, Jonathan Josué; Marizande Lozada, María Fernanda
Parkinson's disease (PD) is a chronic neurodegenerative disorder that affects the central nervous system, manifesting through motor symptoms such as tremors, rigidity and bradykinesia. As research advances, stem cell therapies have emerged as a promising strategy for PD, seeking to improve disease severity and restore motor function. A literature review was conducted to examine the current status of stem cell therapy in the treatment of Parkinson's disease, including recent advances in stem cell research, evaluation of challenges and opportunities in its clinical application. . The methodology used focuses on the compilation of previous studies, scientific articles and clinical trials in order to find the most up-to-date and truthful information. The findings demonstrated that stem cell therapies face ethical challenges in obtaining and manipulating cells, especially with embryonic cells, raising questions about the moral status of the embryo. Obtaining adult stem cells raises ethical dilemmas, including informed consent and the possibility of coercion. The surgical complexity varies depending on the cell source and the transplant method, from embryonic cells to reprogrammed somatic cells, using autografts or allografts. Among the complications, adverse immunological reactions, especially in autografts, represent a potential risk. Finally, addressing ethical challenges, refining surgical techniques, and minimizing complications are imperative to solidify stem cell therapies as effective and ethically acceptable treatments for PD. Keyword