Browsing by Author "Córdova Vega, Génesis Rebeca"

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    Evaluación de la administración de un consorcio microbiano probiótico en la regulación de la glucosa y función lipídica en ratones con diabetes mellitus tipo 2 inducida
    (Universidad Técnica de Ambato. Facultad de Ciencia e Ingeniería en Alimentos y Biotecnología. Carrera de Biotecnología, 2025-02) Córdova Vega, Génesis Rebeca; Garcés Moncayo, María Daniela
    This research arises through the increase of type 2 diabetes mellitus in Ecuador, until 2022, about 1.1 million Ecuadorians suffered from this condition, it is for this reason that it is required to develop new alternatives that allow minimize its effects. The objective of this study is to demonstrate the effect of the probiotic consortium from the province of Santo Domingo de los Tsáchilas in Ecuador, composed of a combination of 10 strains of lactic acid bacteria, among which stands out Leuconostoc mesenteroides, Lactobacillus plantarum, Weissella cibaria and Pediococcus pentosaceus, in the regulation of glucagon-1-like peptide, high-density lipoproteins, low-density lipoproteins and very low-density lipoproteins. To this end, 24 BALB/c mice were given type 2 diabetes mellitus through a high carbohydrate diet for 5 weeks, followed by 0.5 mL of the probiotic consortia administered orally for 4 weeks. The results showed that probiotics stimulated the production of short chain fatty acids, generating a significant increase in secretion of the peptide hormone similar to glucagon 1, improving glycemic control. It was also shown to have the potential to reduce the lipid profile by converting cholesterol into coprostanol and its subsequent fecal elimination. These findings underline the importance of intestinal microbiota in the pathophysiology of diabetes and suggest that the administration of probiotic consortia is a promising complementary therapeutic strategy.