Relación de la proteína C reactiva y la resistencia a la insulina

Abstract

Systemic inflammatory processes are related to glucose metabolism, the effects of which lead to insulin resistance (IR) at the level of the liver, skeletal muscle, and adipose tissue. IR presents as a transition state between normality and the development of type 2 diabetes mellitus, obesity, atherosclerosis, cardiovascular disease. Ultrasensitive C-reactive protein (hsCRP) has been shown to be related to decreased insulin sensitivity, through inflammatory and immune pathways. Objective: To analyze the relationship of hsCRP with the metabolic pathways of insulin resistance. Methods and materials: a bibliographic review was carried out in indexed databases of updated articles in English and Spanish. Meta-analysis, systematic reviews, experimental studies were considered. Results and discussion: The predictive role of CRP in metabolic and cardiovascular diseases was identified in values lower than 3mg/L using ultrasensitive detection methods. The relationship between hsCRP and insulin resistance lies in inflammation of adipose tissue, the secretion of chemokines to attract macrophages, TNF-α and IL-6 as inducers of CRP secretion due to their inflammatory and immune functions. It is not known if the inflammatory response is a cause or a consequence of the alterations in the insulin signal. Conclusions: The hsCRP is a marker with great potential for predicting the state of insulin sensitivity and the development of metabolic diseases