Síndrome de Steven-Johnson y necrólisis epidérmica toxica: revisión bibliográfica actualizada

Abstract

Toxic epidermal necrolysis (TEN) and Steven-Johnson Syndrome (SJS) are acute vesiculobullous mucocutaneous disorders with a high mortality rate. The outcome of this pathology largely depends on identifying the causati ve agent as soon as possible. Followed by supportive care and proper wound management in a burn unit. (1) These pathologies manifest with a prodromal phase very similar to influenza with general malaise, fever that then begins with pain in skin and mucous membranes, whether ocular, genital or oral, to be able to differentiate these pathologies we will base ourselves on the degree of affectation of the skin where <10% corresponds to SJS, the NET presents with >30% involvement while an overlap of SJS/NET goes between 10-30% of skin involvement, if the diagnosis of these pathologies is based on the clinic as well as a histopathological evaluation. (2) Despite having a high mortality rate in recent years, it has decreased considerably, scores such as SCORTEN have been used to determine severity, which has a high predictive factor for assessing severity. (2) In recent studies it has been determined that the triggering factor is certain drugs such as sulfonamias, antiepileptic drugs, non-steroidal anti-inflammatory drugs, as well as the risk of hypersensitivity reactions have been studied as possible triggers