“Niveles séricos de anticuerpos anti-peroxidasa tiroidea (anti-tpo) en sujetos pediátricos con los trastornos del espectro autista (tea) y su correlación con los niveles séricos maternos”,

Abstract

This research project was to determine and to correlate serum levels of anti-TPO antibodies in mothers of pediatric subjects with ASD and their children compared with controls which were mothers and their children with typical development. We analyzed serum levels of anti-TPO antibodies to check if there were a direct association with the development of ASD. Methodologically, it was used a descriptive cross-sectional and correlational analysis; doing the research in field and laboratory. We worked with 88 patients, of which 30 were pediatric subjects aged between 3 - 17 years of age with Autism Spectrum Disorders, their mothers, and 14 children with neurotypical development and their mothers, who underwent the quantitative analysis of serum levels of anti-TPO. The quantification of serum levels of anti-TPO was carried out using the test method of enzyme-linked immunosorbent assay (ELISA). For the correlation of serum levels of anti-TPO of ASD children and their mothers we use statistical methods of Odds Ratio (OR), and Pearson. The analysis determined that 100% of the pediatric subjects with ASD presented normal serum (values of less than 40IU/ml): 3.3% of the mothers of the pediatric subjects with ASD presented high serum levels of anti-TPO antibodies (greater than 40IU/ml). On the other hand the 7.1% of the mothers of children with typical development presented high serum levels of anti-TPO antibodies. The analysis of correlation (r) of anti-TPO antibodies serum levels in pediatric subjects with ASD and their mothers presented a Pearson´s correlation of 0.207. The correlation of anti-TPO antibodies serum levels in pediatric subjects with typical development and their mothers presented a negative very low Pearson´s correlation of –0.01. Concluding that the serum levels of anti-TPO antibodies of mothers has no correlation with the development of ASD.