“Niveles séricos del perfil tiroideo en sujetos pediátricos con los trastornos del espectro autista y su correlación con los niveles séricos maternos”

Abstract

The present investigation was carried out with the objective of analyzing the serum levels of the thyroid profile: thyroid stimulating hormone (TSH), triiodothyronine (T3) and thyroxine (T4) in pediatric subjects with autism spectrum disorders (ASD) and its correlation With maternal serum levels, the purpose was to relate whether mothers with high values of the aforementioned hormones influenced their children to develop ASD. The methodology was based on a quantitative approach using field and laboratory research. We worked with a total of 88 patients; of which were 30 pediatric subjects with Autism Spectrum Disorders aged 3-17 years together with their 30 mothers, and 14 subjects with typical development and their mothers respectively. The serum levels of thyrotropin, triiodothyronine and toroxin were evaluated. TSH values in mothers of children with ASD and those of their children showed a very low positive correlation (r = 0.182, p = 0.337). In T3 there is a very low positive correlation (r = 0.013, p = 0.945). While in T4 there is a very low positive correlation (r = 0.145). (p = 0.445). The ODDS RATIO TSH statistical study of children with ASD and DT compared with their mothers, respectively, obtained a low probability, with an OR = 0.302, with an IC of 95%, 0.192 - 0.476. In hormone T3 there is a low probability, OR = 0.576, with an IC of 95%, 0.430 - 0.772. In case of hormone T4 the probability low, OR = 0.750, with an IC of 95%, 0.165 - 3.400. The serum levels of the thyroid profile were correlated: T3, T4 and TSH in pediatric subjects with ASD and their mothers where we did not obtain any kind of relationship; so the null hypothesis was accepted. Finally, the serum levels of the thyroid profile were correlated: T3, T4 and TSH in pediatric subjects with typical development with their mothers, no relation was obtained