Epidemiología y nuevas dianas moleculares en el cáncer de mama

Abstract

Breast cancer is the leading cause of cancer morbidity and mortality in women worldwide. Ecuador also does not escape this health problem where deaths from breast cancer exceed other neoplasms in women. It is distributed throughout the country, although Quito is the city with the highest incidence levels and its mortality has not decreased in the last 40 years, despite advances in diagnosis and treatment. Objective: To evaluate the best available scientific evidence about epidemiology and new molecular targets in breast cancer for diagnostic and therapeutic purposes. Methods: A meta-analysis was carried out with a systematic review of the literature using the PRISMA methodology, on the new molecular targets for diagnostic and therapeutic purposes in Breast Cancer by searching for articles in the wos, Scopus, PubMed, ProQuest, Embase, Redalyc, Ovid, Medline, DynaMed and ClinicalKey databases during the period 2017-2022. Results: he systematic review provided a total of 38,542 records, of which 100 were eligible; of these, 60 did not provide new data, including 40 scientific articles. Conclusion: Breast cancer is a relevant cause of morbidity and mortality and disability in women worldwide, the detection of new molecular targets for diagnostic and therapeutic purposes opens new possibilities for the control and / or cure of this malignancy.